Even slight changes may indicate that something may be wrong. Paleness could be a sign of anemia. A yellow tone could indicate liver disease. A bluish tint in lips or nail beds could indicate heart or lung disease, says Mallika Marshall, MD, an internist and pediatrician at Massachusetts General Hospital.
Rashes and blotches
Certain digestive problems may show up on skin, says Dr. Raj. Itchy clusters of red bumps could indicate celiac disease, an autoimmune disorder in which the body reacts to gluten. A butterfly-shaped rash across the cheekbones and over the bridge of the nose can be a sign of lupus, an autoimmune disease. Allergies, eczema and rosacea, and certain infections can also trigger facial rashes.