Snakeroot extract comes from plants of the sunflower family. A study conducted at the Biomedical Laboratory of the Instituto Mexicano del Seguro Social found that snakeroot extract was an effective treatment for toenail fungus The study involved 96 participants. Forty-nine were treated with an active compound form of snakeroot leaf extract and 47 were given eight percent ciclopirox topical treatment. Researchers found that snakeroot extract was just as effective for toenail fungus as some prescription medications, when applied topically to affected area. To try it yourself, apply every third day for the first month, twice a week for the second month and once a week for the third month.